Tert-Butylamine → HCID 3086994, compound

HRID 1768975Notes

Reaction equation

HRID 1768975 reaction equation
[O:1]1[CH2:3][CH:2]1[CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[NH:12][C:13]([C:15]1[C:16]2[CH:17]=[CH:18][NH:19][C:20]=2[CH:21]=[CH:22][CH:23]=1)=[O:14].[C:24]([NH2:28])([CH3:27])([CH3:26])[CH3:25]>C(O)C>[CH3:25][C:24]([NH:28][CH2:3][CH:2]([OH:1])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[NH:12][C:13]([C:15]1[C:16]2[CH:17]=[CH:18][NH:19][C:20]=2[CH:21]=[CH:22][CH:23]=1)=[O:14])([CH3:27])[CH3:26]

Participants

4

Reactant 2

HCID 6385Tert-ButylamineHCID 13787418HCID 13787418, compound

Product 1

HCID 3086994HCID 3086994, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2.8 g of the product from Step C for 1 hour in 40 ml of ethanol and 7.6 ml of tert-butylamine was heated at 80° C. under an inert atmosphere with stirring and after purification by chromatography over silica (eluent:ethyl acetate--triethylamine, 9-1, then chloroform-methanol 5-5), 3.05 g of N-[2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]phenyl]-1H-indol-4-carboxamide were obtained (amorphous beige--colored powder).

Workup

  1. customafter purification by chromatography over silica (eluent

Sources & evidence

ORD record
ord-04491726527c4cc0a3a59eb2034230ff
Source dataset
uspto-grants-1995_01
Patent number
US05380722

Reaction notes

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