Dimethyl Sulfoxide → HCID 18946530, compound

HRID 1769017Notes

Reaction equation

HRID 1769017 reaction equation
[F:1][C:2]([F:24])([F:23])[C:3]1[C:4]([O:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][OH:22])=[N:5][CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.CS(C)=O.C(N(CC)CC)C>ClCCl>[F:23][C:2]([F:1])([F:24])[C:3]1[C:4]([O:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH:21]=[O:22])=[N:5][CH:6]=[C:7]([C:9]([F:12])([F:10])[F:11])[CH:8]=1

Participants

5

Reactant 3

HCID 679Dimethyl SulfoxideHCID 8471TriethylamineHCID 18946541HCID 18946541, compound

Product 1

HCID 18946530HCID 18946530, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The above alcohol (0.6 g) was oxidised under Swern conditions (dimethyl sulphoxide (0.26 g) oxalyl chloride (160 μl), triethylamine (1.0 ml)) in dichloromethane (30 ml) to give 8-(3,5-bistrifluoromethyl-2-pyridyloxy)octan-1-al. This was used directly in the next stage.

Sources & evidence

ORD record
ord-821eb56333a94ad881fc0ad072cf7604
Source dataset
uspto-grants-1995_01
Patent number
US05380732

Reaction notes

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