反应详情

To 10 ml of tetrahydrofuran solution containing 0.52 g of 4-bromo-2-mercapto-6-methylbenzothiazole was added 50 mg of sodium hydride at 0° C. After adding 0.28 g of n-bromobutane, the whole mixture was refluxed for 2 hours, distilled under reduced pressure to remove tetrahydrofuran and then extracted with ethyl acetate by adding water and ethyl acetate. The ethyl acetate layer was dried with anhydrous sodium sulfate and evaporated under reduced pressure to obtain the title compound in a yellow liquid state (Yield: 66%).

1. temperaturethe whole mixture was refluxed for 2 hours
2. distillationdistilled under reduced pressure
3. customto remove tetrahydrofuran
4. extractionextracted with ethyl acetate
5. additionby adding water and ethyl acetate
6. dry with materialThe ethyl acetate layer was dried with anhydrous sodium sulfate
7. customevaporated under reduced pressure