反应详情

Mix 1-[(1-carbomethoxy methoxy ethyl)-1H-benzimidazol-2-yl][1-(t-butyloxycarbonyl)-4-piperidinyl]methanone (11.9 g, 26.67 mmol) and trifluoroacetic acid (75 mL). Stir at room temperature until the reaction is complete. Pour onto water and carefully neutralize with solid sodium hydrogen carbonate. Extract into ethyl acetate (2×), wash with brine and dry (MgSO4). Evaporate the solvent in vacuo and purify by chromatography to give the title compound.

1. additionPour onto water
2. extractionExtract into ethyl acetate (2×)
3. washwash with brine
4. dry with materialdry (MgSO4)
5. customEvaporate the solvent in vacuo
6. custompurify by chromatography