反应详情

温度

90 °C

Mix [1H-benzimidazol-2-yl][1-(t-butyloxycarbonyl)-4-piperidinyl]methanone (4.25 g, 12.91 mmol), 5-bromovaleronitrile (2.5 g, 15.3 mmol), potassium carbonate (5.29 g, 38.25 mmol) and dimethylformamide (100 mL). Stir and heat and at 90° C. overnight. Allow to cool to room temperature, dilute with water and extract with ethyl acetate (2×). Wash the combined organic phases with water (3×), then brine and dry (MgSO4). Evaporate the solvent in vacuo and purify by chromatography to give the title compound.

1. temperatureto cool to room temperature
2. extractionextract with ethyl acetate (2×)
3. washWash the combined organic phases with water (3×)
4. dry with materialbrine and dry (MgSO4)
5. customEvaporate the solvent in vacuo
6. custompurify by chromatography