Hydrogen Bromide → HCID 18947065, compound

HRID 1769094Notes

Reaction equation

HRID 1769094 reaction equation
[C:1]([C:4]1[S:5][CH:6]=[C:7]2[CH2:11][N:10](S(C3C=CC(C)=CC=3)(=O)=O)[CH2:9][C:8]=12)([OH:3])=[O:2].[BrH:22]>C(O)(=O)C>[BrH:22].[C:1]([C:4]1[S:5][CH:6]=[C:7]2[CH2:11][NH:10][CH2:9][C:8]=12)([OH:3])=[O:2]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 18947048HCID 18947048, compound

Product 1

HCID 18947065HCID 18947065, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of 0.5 g (1.54 mmol) of 1-carboxy-5-tosyl-5,6-dihydro-4H-thieno[3,4-c]pyrrole and 5 ml of a 33% solution of hydrobromic acid in acetic acid, placed in a sealed tube, is heated at 60° C. in a water bath for 15 min. The reaction mixture is then cooled, the precipitate formed is filtered, washed twice with diethyl ether and dried. 0.32 g of product is obtained in the hydrobromide form. Yield 83%. Melting point: 281.3°-281.7° C.

Workup

  1. customplaced in a sealed tube
  2. temperatureThe reaction mixture is then cooled
  3. customthe precipitate formed
  4. filtrationis filtered
  5. washwashed twice with diethyl ether
  6. customdried

Sources & evidence

ORD record
ord-2287cbf3cb854a82a8e957af7c0084b0
Source dataset
uspto-grants-1995_01
Patent number
US05380742

Reaction notes

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