Hydrochloric Acid → HCID 18947060, compound

HRID 1769095Notes

Reaction equation

HRID 1769095 reaction equation
[ClH:1].Br.[C:3]([C:6]1[S:7][CH:8]=[C:9]2[CH2:13][NH:12][CH2:11][C:10]=12)([OH:5])=[O:4].[CH2:14](O)[CH3:15]>>[ClH:1].[CH2:14]([O:4][C:3]([C:6]1[S:7][CH:8]=[C:9]2[CH2:13][NH:12][CH2:11][C:10]=12)=[O:5])[CH3:15]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 18947065HCID 18947065, compound

Product 1

HCID 18947060HCID 18947060, compoundYield 80%

Procedure

A stream of hydrochloric acid is passed into a suspension of 3.3 g (13.2 mmol) of 1-carboxy-5,6-dihydro-4H-thieno[3,4-c]pyrrole hydrobromide in 75 ml of ethanol, heated at reflux for 4 h. The solvent is then evaporated and the residue triturated with twice 20 ml of diethyl ether. 2.46 g of a beige solid are obtained. Yield 80%. Melting point: 163° C. (with decomposition).

Workup

  1. temperatureheated
  2. temperatureat reflux for 4 h
  3. customThe solvent is then evaporated
  4. customthe residue triturated with twice 20 ml of diethyl ether

Sources & evidence

ORD record
ord-c712191b1af448b6aa54566ad7764d5f
Source dataset
uspto-grants-1995_01
Patent number
US05380742

Reaction notes

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