Imidazole → HCID 67715872, compound

HRID 1769107Notes

Reaction equation

HRID 1769107 reaction equation
[F:1][C:2]1[CH:17]=[CH:16][C:5]([CH:6]=[C:7]2[C:11]3([O:13][CH2:12]3)[C:10]([CH3:15])([CH3:14])[CH:9]=[CH:8]2)=[CH:4][CH:3]=1.[NH:18]1[CH:22]=[CH:21][N:20]=[CH:19]1.C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[F:1][C:2]1[CH:17]=[CH:16][C:5]([CH:6]=[C:7]2[CH:8]=[CH:9][C:10]([CH3:15])([CH3:14])[C:11]2([CH2:12][N:18]2[CH:22]=[CH:21][N:20]=[CH:19]2)[OH:13])=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 795ImidazoleHCID 962WaterHCID 11430Potassium CarbonateHCID 54497899HCID 54497899, compound

Product 1

HCID 67715872HCID 67715872, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 7-(4-fluorobenzylidene)-4,4-dimethyl-1-oxaspiro[2.4]hept-5-ene (5.5 g), produced according to the previous example, with imidazole (2 g) and potassium carbonate (6.6 g) is heated in N,N-dimethylformamide (50 cc) for 4 hours. The mixture is poured into water and extracted with ethyl acetate. The organic phase is washed, dried and recrystallized to obtain the product indicated, m.p. 172° C., compound no. 32.

Workup

  1. customproduced
  2. extractionextracted with ethyl acetate
  3. washThe organic phase is washed
  4. customdried
  5. customrecrystallized
  6. customto obtain the product

Sources & evidence

ORD record
ord-e198f06c8d7d43e68af1b2ad1d94e64f
Source dataset
uspto-grants-1995_01
Patent number
US05380743

Reaction notes

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