Hydrochloric Acid → HCID 54362222, compound

HRID 1769581Notes

Reaction equation

HRID 1769581 reaction equation
C1COCC1.Cl.[F:7][C:8]1[CH:9]=[C:10]([CH2:16][CH2:17][CH:18]2[CH2:23][CH2:22][C:21](=[CH:24][O:25]C)[CH2:20][CH2:19]2)[CH:11]=[C:12]([F:15])[C:13]=1[F:14]>O>[F:7][C:8]1[CH:9]=[C:10]([CH2:16][CH2:17][CH:18]2[CH2:23][CH2:22][CH:21]([CH:24]=[O:25])[CH2:20][CH2:19]2)[CH:11]=[C:12]([F:15])[C:13]=1[F:14]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 86748404HCID 86748404, compound

Product 1

HCID 54362222HCID 54362222, compoundYield 89.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

THF (100 ml) and 2N-hydrochloric acid (100 ml) were added to 4-(2'-(3",4",5"-trifluorophenyl)ethyl)methoxymethylenecyclohexane (20 g), followed by heating the mixture under reflux with stirring for 2 hours, adding to water (300 ml) after completion of the reaction, extracting with ethyl acetate (300 ml), drying the organic layer over anhydrous MgSO4 and concentrating under reduced pressure, to obtain 4-(2'-(3",4",5"-trifluorophenyl)ethyl)cyclohexane carbaldehyde (17 g).

Workup

  1. temperatureby heating the mixture
  2. temperatureunder reflux
  3. customafter completion of the reaction
  4. extractionextracting with ethyl acetate (300 ml)
  5. dry with materialdrying the organic layer over anhydrous MgSO4
  6. concentrationconcentrating under reduced pressure

Sources & evidence

ORD record
ord-a86eb0de5c784bfd991acfea9fe2acf4
Source dataset
uspto-grants-1995_01
Patent number
US05382379

Reaction notes

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