Hydrogen Bromide → HCID 20096775, compound

HRID 1769585Notes

Reaction equation

HRID 1769585 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:10]2[CH2:15][CH2:14][CH:13]([CH2:16][CH2:17]O)[CH2:12][CH2:11]2)[CH:5]=[C:6]([F:9])[C:7]=1[F:8].[BrH:19]>O>[F:1][C:2]1[CH:3]=[C:4]([CH:10]2[CH2:15][CH2:14][CH:13]([CH2:16][CH2:17][Br:19])[CH2:12][CH2:11]2)[CH:5]=[C:6]([F:9])[C:7]=1[F:8]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 20096777HCID 20096777, compound

Product 1

HCID 20096775HCID 20096775, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4-(3',4',5'-Trifluorophenyl)-1-(2'-hydroxyethyl)cyclohexane (10.4 g) was added to an aqueous solution of 47% HBr (15 ml), followed by stirring the mixture under reflux for 2 hours, adding the reaction solution to water (50 ml), extracting with ethyl acetate (100 ml), washing the organic layer with water, drying over anhydrous MgSO4, and concentrating the solvent under reduced pressure, to obtain 4-(3',4',5'-trifluorophenyl)-1 -(2'-bromoethyl)cyclohexane (10.4g).

Workup

  1. temperatureunder reflux for 2 hours
  2. extractionextracting with ethyl acetate (100 ml)
  3. washwashing the organic layer with water
  4. dry with materialdrying over anhydrous MgSO4
  5. concentrationconcentrating the solvent under reduced pressure

Sources & evidence

ORD record
ord-3c920d3407ac4374886efeb8579b60ef
Source dataset
uspto-grants-1995_01
Patent number
US05382379

Reaction notes

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