2-Methoxyethylamine → HCID 20096999, compound

HRID 1769593Notes

Reaction equation

HRID 1769593 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][NH2:5].CO[C:8]1[C:9]2[C:10](=[N:14][O:15][N+:16]=2[O-:17])[N:11]=[CH:12][N:13]=1>CO>[CH3:1][O:2][CH2:3][CH2:4][NH:5][C:8]1[C:9]2[C:10](=[N:14][O:15][N+:16]=2[O-:17])[N:11]=[CH:12][N:13]=1

Participants

4

Reactant 2

HCID 80182-MethoxyethylamineHCID 3104939[1,2,5]Oxadiazolo[3,4-d]pyrimidine, 7-methoxy-, 1-oxide

Product 1

HCID 20096999HCID 20096999, compoundYield 68%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A solution of 1.8 g (24 mmol) of methoxyethylamine in 5 ml of methanol is added dropwise to a suspension of 4.0 g (24 mmol) of 7-methoxy[1,2,5]oxadiazolo[3,4-d]pyrimidine-1-oxide in 120 ml of methanol. The starting material goes into solution and immediately thereafter the product precipitates from the reaction mixture. After 30 minutes, the precipitate is filtered off with suction and washed with methanol. 3.4 g (68%) of 7-(2-methoxyethylamino)-[1,2,5]oxadiazolo[3,4-d]pyrimidine-1-oxide are obtained.

Workup

  1. customimmediately thereafter the product precipitates from the reaction mixture
  2. filtrationthe precipitate is filtered off with suction
  3. washwashed with methanol

Sources & evidence

ORD record
ord-fcc313536fb246f1bcdfa76118aa85db
Source dataset
uspto-grants-1995_01
Patent number
US05382585

Reaction notes

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