反应详情

温度

-15 °C

A solution of 1-hydroxycyclopropanecaboxylic acid (0.66 g, 6.44 mmol) in dry dimethylacetamide (10 ml) was stirred under a nitrogen atmosphere at -15° C. Thionyl chloride (0.77 g, 6.44 mmol) was added and the resulting mixture was allowed to stir at -15° C. for 1 hour. 4-Phenylsulfonylaniline (1.0 g, 4.29 mmol) was then added and the reaction mixture was stirred at -15° C. for a further 15 mins. The solution was then allowed to warm to room temperature where it was stirred overnight. The reaction mixture was poured onto ice, extracted with ethyl acetate, and the combined ethyl acetate portions were washed with 1M HCl. After drying (MgSO4) the ethyl acetate was removed by evaporation to give a buff-colored solid. Crystallization of this material from ethyl acetate/hexane yielded the title tertiary carbinol, (0.82 g, 60%) as a white solid; mp=214.5°-216° C. 1H-NMR (250 MHz, d6 -DMSO): 0.98 (m, 2H, 2 CH2), 1.15 (m, 2H, CH2), 6.63 (s, 1H, OH), 7.65 (m, 3H, ArH), 7.95 (m, 6H, ArH), 10.29 (s, 1H, NH). MS (CI, CH4): 318(M+1, 100).

1. stirringthe reaction mixture was stirred at -15° C. for a further 15 mins
2. temperatureto warm to room temperature where it
3. stirringwas stirred overnight
4. additionThe reaction mixture was poured onto ice
5. extractionextracted with ethyl acetate
6. washthe combined ethyl acetate portions were washed with 1M HCl
7. dry with materialAfter drying (MgSO4) the ethyl acetate
8. customwas removed by evaporation
9. customto give a buff-colored solid
10. customCrystallization of this material from ethyl acetate/hexane
11. customyielded the title tertiary carbinol, (0.82 g, 60%) as a white solid