2,2,2-Trifluoroethanol → 2,2,2-Trifluoroethyl trifluoromethanesulfonate

HRID 1769837Notes

Reaction equation

HRID 1769837 reaction equation
FC(F)(F)S([O:6][S:7]([C:10]([F:13])([F:12])[F:11])(=[O:9])=[O:8])(=O)=O.[F:16][C:17]([F:21])([F:20])[CH2:18]O>>[F:13][C:10]([F:11])([F:12])[S:7]([O:6][CH2:18][C:17]([F:21])([F:20])[F:16])(=[O:8])=[O:9]

Participants

3

Reactant 2

HCID 64092,2,2-TrifluoroethanolHCID 67749Trifluoromethanesulfonic anhydride

Product 1

HCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonateYield 73%

Procedure

In a 100-ml flask equipped with a stirrer, a thermometer, a nitrogen introducing pipe and a condenser, 50 ml (0.297 mol) of trifluoromethanesulfonic anhydride and 25 ml (0.342 mole) of 2,2,2-trifluoroethanol were placed at room temperature and stirred for 30 minutes in a nitrogen atmosphose, followed by reflux for 3 hours. After distillation, 50.3 g of 2,2,2-trifluoroethyl trifluoromethanesulfonate was obtained in yield of 73%.

Workup

  1. customIn a 100-ml flask equipped with a stirrer
  2. customwere placed at room temperature
  3. temperatureby reflux for 3 hours
  4. distillationAfter distillation

Sources & evidence

ORD record
ord-5db3413241b240f089f8e33c9190bbf0
Source dataset
uspto-grants-1995_01
Patent number
US05382687

Reaction notes

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