反应详情

POCl3 (6.13 g) was added to stirred DMF (7 ml) at 0° C. and the mixture was stirred for 30 minutes at room temperature. The mixture was added dropwise to a solution of 1-phenylpyrrolidine (5.0 g) in DMF (30 ml) at 0° C. and the resulting solution was stirred overnight at room temperature. The reaction mixture was poured into an ice water mixture and extracted with Et2O. The Et2O layer was washed with saturated NaCl solution, dried over MgSO4 and the solution was concentrated in vacuo. The resulting crystalline mass was washed with Et2O-hexane, yielding 1-(4-formylphenyl)pyrrolidine (3.28 g). ##STR6##

1. stirringthe resulting solution was stirred overnight at room temperature
2. extractionextracted with Et2O
3. washThe Et2O layer was washed with saturated NaCl solution
4. dry with materialdried over MgSO4
5. concentrationthe solution was concentrated in vacuo
6. washThe resulting crystalline mass was washed with Et2O-hexane