反应详情

A mixture of 0.97 g 4-(3-t-butylureidomethyl)-1-aminomethylbenzene obtained in Example 8, 0.57 g anhydrous potassium carbonate and 20 ml dimethylformamide was stirred at room temperature for 30 minutes, 0.93 g 1-iodoheptane was added, and stirring was continued at room temperature for an additional three hours. After distilling off the solvent under reduced pressure, the residue was extracted with chloroform, and the extract was washed with water. The chloroform was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography, giving 0.65 g of 4-(3-t-butylureidomethyl)-1-(N-heptylaminomethyl)benzene.

1. stirringstirring
2. waitwas continued at room temperature for an additional three hours
3. distillationAfter distilling off the solvent under reduced pressure
4. extractionthe residue was extracted with chloroform
5. washthe extract was washed with water
6. distillationThe chloroform was distilled off under reduced pressure
7. customthe residue was purified by silica gel column chromatography