反应详情

5.0 g (0.03 mol) of methyl 2-hydroxy-6-methylnicotinate, 5.0 g (0.03 mol) of potassium carbonate, 5.7 g (0.03 mol) of 2-chloro-4,6-dimethoxypyrimidine and 50 ml of N,N-dimethylformamide were weighed, and were reacted at 100° C. for 4 hours. The reaction mixture was then poured into water, and was extracted with 100 ml of ethyl acetate. The organic layer was then washed with water and a saturated sodium chloride aqueous solution. After drying with anhydrous sodium sulfate, the solvent was distilled off, and the residue was purified by silica gel column chromatography to obtain 0.73 g of the aimed product.

1. customwere reacted at 100° C. for 4 hours
2. extractionwas extracted with 100 ml of ethyl acetate
3. washThe organic layer was then washed with water
4. dry with materialAfter drying with anhydrous sodium sulfate
5. distillationthe solvent was distilled off
6. customthe residue was purified by silica gel column chromatography