反应详情

0.53 g (1.93 mM of 2-octylindan-5-boronic acid, 0.80 g (1.73 mM) of 2-fluoro-4-(5-decylpyrimidine-2-yl)phenyl triflate, 1.5 ml of ethanol, 2.7 ml of toluene, 2.7 ml of 2M-sodium carbonate aqueous solution and 0.09 g of tetrakis (triphenylphosphine) palladium (0) were mixed and heat-refluxed for 130 minutes under stirring. After the reaction, the reaction mixture, water and toluene were added to followed by filtration under reduced pressure. The toluene layer was washed with a common salt aqueous solution followed by drying with anhydrous sodium sulfate. Then, the sodium sulfate was removed from the mixture and the resultant mixture was evaporated to obtain a residue. The residue was purified by silica gel column chromatography (eluent: toluene) and recrystallized from a mixture solvent (toluene/methanol) to obtain 0.81 g of 2-octyl-5-[2-fluoro-4-(5-decylpyrimidine-2-yl)phenyl]indan (Yield: 86.3%). ##STR314##

1. temperatureheat-refluxed for 130 minutes
2. customAfter the reaction
3. filtrationto followed by filtration under reduced pressure
4. washThe toluene layer was washed with a common salt aqueous solution
5. dry with materialby drying with anhydrous sodium sulfate
6. customThen, the sodium sulfate was removed from the mixture
7. customthe resultant mixture was evaporated
8. customto obtain a residue
9. customThe residue was purified by silica gel column chromatography (eluent: toluene)
10. customrecrystallized from a mixture solvent (toluene/methanol)