Gamma-Butyrolactone → HCID 15767531, compound

HRID 1770244Notes

Reaction equation

HRID 1770244 reaction equation
[CH2:1]([O:5][CH2:6][CH2:7][CH2:8][NH2:9])[CH2:2][CH2:3][CH3:4].[C:10]1(=O)[O:14][CH2:13][CH2:12][CH2:11]1>>[CH2:1]([O:5][CH2:6][CH2:7][CH2:8][N:9]1[CH2:10][CH2:11][CH2:12][C:13]1=[O:14])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 7302Gamma-ButyrolactoneHCID 854611-Propanamine, 3-butoxy-

Product 1

HCID 15767531HCID 15767531, compound

Conditions

Temperature
275 °C

Procedure

360 grams of butoxypropylamine (2.75 moles) and 250 grams of butyrolactone (3.0 moles) were charged to a 1-liter stainless steel autoclave. After purging, the mixture was heated to 275° C. for six hours. The reactor was then cooled and the product discharged. The product was distilled with a simple Vigreux column, initially at atmospheric pressure to remove by-product water and then under vacuum (<1 mm) to recover the product. Butoxypropyl Pyrrolidone distills at about 135° C. to 145° C. under these conditions. The recovery was 391.2 grams of>98% pure Butoxypropyl Pyrrolidone.

Workup

  1. customAfter purging
  2. temperatureThe reactor was then cooled
  3. distillationThe product was distilled with a simple Vigreux column, initially at atmospheric pressure
  4. customto remove by-product water
  5. customunder vacuum (<1 mm) to recover the product
  6. distillationButoxypropyl Pyrrolidone distills at about 135° C. to 145° C. under these conditions

Sources & evidence

ORD record
ord-75d11de14ffa412db492ba6279f9d9b4
Source dataset
uspto-grants-1995_01
Patent number
US05385948

Reaction notes

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