Hydrogen Bromide → 2-Carboxyethyl 5-amino-4-oxopentanoate hydrobromide

HRID 1771031Notes

Reaction equation

HRID 1771031 reaction equation
C([NH:8][CH2:9][C:10](=[O:25])[CH2:11][CH2:12][C:13]([O:15][CH2:16][CH2:17][C:18]([O:20]C(C)(C)C)=[O:19])=[O:14])(OC(C)(C)C)=O.[BrH:26]>C(O)(=O)C>[BrH:26].[NH2:8][CH2:9][C:10](=[O:25])[CH2:11][CH2:12][C:13]([O:15][CH2:16][CH2:17][C:18]([OH:20])=[O:19])=[O:14]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 900345122-(t-butoxycarbonyl)ethyl 5-(Boc-amino)-4-oxopentanoate

Product 1

HCID 900344812-Carboxyethyl 5-amino-4-oxopentanoate hydrobromideYield 79%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

This compound was prepared from the product of 4a (5.43 g; 15.1 mmol) and 30% HBr in acetic acid (15 mL) according to Example 1c. 3.38 g (79%) product was obtained (amber gum that did not solidify).

Sources & evidence

ORD record
ord-aadb54df4689413ba507b93820dbae30
Source dataset
uspto-grants-2016_02
Patent number
US09249086B2

Reaction notes

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