反应详情

This compound was prepared from 5-(Boc-amino)-4-oxopentanoic acid (1.97 g; 8.5 mmol), the product of 6a (2.35 g; 8.7 mmol), and triethylamine (0.88 g; 8.7 mmol) in ethyl acetate (30 mL) as described in Example 1a. The crude product was purified by flash chromatography on a 65×55 mm silica gel 60 column eluted with ethyl acetate-hexane (1:2) (1100 mL) collecting 18×50 mL fractions. After evaporation of fractions 3-8, 2.79 g (78%) product was obtained (amber oil).

1. customThe crude product was purified by flash chromatography on a 65×55 mm silica gel 60 column
2. washeluted with ethyl acetate-hexane (1:2) (1100 mL)
3. customcollecting 18×50 mL fractions
4. customAfter evaporation of fractions 3-8