反应详情

A stirred mixture of the product from 8c (0.70 g; 1.54 mmol), 12 M HCl (0.13 mL; 1.54 mmol), 10% Pd/C (Degussa type E101 NE/W) (100 mg), and 2-propanol (25 mL) was hydrogenated at ambient temperature and 4 bars pressure overnight. The mixture was filtered through a Celite® 545 pad; the filtrate was evaporated and the residue was triturated with dry diethyl ether (3×5 mL). After drying of the residue at ambient temperature and 0.01 mm Hg, 0.38 g (97%) product was obtained (white solid).

1. customwas hydrogenated at ambient temperature
2. custom4 bars pressure overnight
3. filtrationThe mixture was filtered through a Celite® 545 pad
4. customthe filtrate was evaporated
5. customthe residue was triturated with dry diethyl ether (3×5 mL)
6. customAfter drying of the residue at ambient temperature