Hydrochloric Acid → HCID 90034551, compound

HRID 1771051Notes

Reaction equation

HRID 1771051 reaction equation
C([NH:11][CH2:12][C:13](=[O:37])[CH2:14][CH2:15][C:16]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][C:27]([O:29]CC1C=CC=CC=1)=[O:28])=[O:17])(OCC1C=CC=CC=1)=O.[ClH:38].[H][H]>[Pd].CC(O)C>[ClH:38].[NH2:11][CH2:12][C:13](=[O:37])[CH2:14][CH2:15][C:16]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][C:27]([OH:29])=[O:28])=[O:17]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 90034514HCID 90034514, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 90034551HCID 90034551, compoundYield 62%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 3776IsopropanolSolvent

Procedure

This compound was prepared from the product of 11c (1.4 g; 2.7 mmol), 12 M HCl (0.25 mL; 3.0 mmol), 10% Pd/C (100 mg), hydrogen gas, and 2-propanol (25 mL) using the procedure in Example 8d. 0.54 g (62%) product was obtained (white solid).

Sources & evidence

ORD record
ord-8d8924e3279d47d8bf550a8ca0f9e02e
Source dataset
uspto-grants-2016_02
Patent number
US09249086B2

Reaction notes

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