反应详情

To a solution of (2,6-difluoro-3-hydroxyphenyl)(quinoxalin-6-yl)methanone (57 mg, 0.2 mmol, 1.0 eq.) in CH3CN (10 mL) were added K2CO3 (56 mg, 0.4 mmol, 2 eq.) and (bromomethyl)benzene (38 mg, 0.22 mmol, 1.1 eq). The resulting mixture was stirred at rt overnight, then concentrated. The residue was purified via flash column chromatography (PE/EA=10/1, v/v) to afford (3-(benzyloxy)-2,6-difluorophenyl)(quinoxalin-6-yl)methanone as brown solid (38.4 mg, 51.2%). LRMS (M+H+) m/z calculated 377.1, found 377.1. 1H NMR (CDCl3, 400 MHz) δ 8.93-8.95 (d, 2 H), 8.48 (s, 1 H), 8.39-8.41 (d, 1 H), 8.23-8.26 (d, 1 H), 7.33-7.45 (m, 5 H), 7.10-7.16 (m, 1 H), 6.91-6.95 (t, 1 H), 5.17 (s, 2 H).

1. concentrationconcentrated
2. customThe residue was purified via flash column chromatography (PE/EA=10/1