Selenium Dioxide → HCID 86676113, compound

HRID 1771283Notes

Reaction equation

HRID 1771283 reaction equation
[CH3:1][C:2]([C:4]1[CH:9]=[C:8]([Cl:10])[CH:7]=[C:6]([F:11])[CH:5]=1)=[O:3].[Se](=O)=[O:13]>>[Cl:10][C:8]1[CH:9]=[C:4]([C:2](=[O:3])[CH:1]=[O:13])[CH:5]=[C:6]([F:11])[CH:7]=1

Participants

3

Reactant 2

HCID 24007Selenium DioxideHCID 27575311-(3-Chloro-5-fluorophenyl)ethan-1-one

Product 1

HCID 86676113HCID 86676113, compoundYield 84%

Procedure

(3-Chloro-5-fluorophenyl)(oxo)acetaldehyde (27 g, 84%) was prepared from 3-chloro-5-fluoro acetophenone (30.0 g, 174.4 mmol) and selenium dioxide (21.28 g, 191.8 mmol) according to the typical procedure used for Preparation 1.

Workup

  1. customused for Preparation 1

Sources & evidence

ORD record
ord-95c8f8c2708b43dc8835642f3911bbc5
Source dataset
uspto-grants-2016_02
Patent number
US09249130B2

Reaction notes

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