Ammonia → 5-Phenyl-1,2,4-triazin-3-amine

HRID 1771291Notes

Reaction equation

CS([C:5]1[N:6]=[N:7][CH:8]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:10]=1)(=O)=O.[NH3:17].C1COCC1>>[C:11]1([C:9]2[N:10]=[C:5]([NH2:17])[N:6]=[N:7][CH:8]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

Reactant 3

HCID 222Ammonia

HCID 8028Tetrahydrofuran

HCID 109882213-(Methylsulfonyl)-5-phenyl-1,2,4-triazine

Product 1

HCID 970815-Phenyl-1,2,4-triazin-3-amineYield 73%

Procedure

5-Phenyl-1,2,4-triazin-3-amine (1.70 g, 73%) was prepared from 3-(methylsulfonyl)-5-phenyl-1,2,4-triazine (3.20 g, 13.6 mmol) and 0.5 M ammonia in THF (100 mL, 500 mmol) according to the general procedure of Preparation 2.

Workup

customaccording to the general procedure of Preparation 2

Sources & evidence

ORD record: ord-6c786a2bdeae4ca6b0c89652b82d21b9
Source dataset: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09249130B2

Reaction notes

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