Ammonia → 5-(4-Fluoro-phenyl)-[1,2,4]triazin-3-ylamine

HRID 1771297Notes

Reaction equation

HRID 1771297 reaction equation
CS([C:5]1[N:6]=[N:7][CH:8]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[N:10]=1)(=O)=O.[NH3:18].C1COCC1>>[F:17][C:14]1[CH:15]=[CH:16][C:11]([C:9]2[N:10]=[C:5]([NH2:18])[N:6]=[N:7][CH:8]=2)=[CH:12][CH:13]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 8028TetrahydrofuranHCID 67362865HCID 67362865, compound

Product 1

HCID 71760885-(4-Fluoro-phenyl)-[1,2,4]triazin-3-ylamineYield 74%

Procedure

5-(4-Fluorophenyl)-1,2,4-triazin-3-amine (2.80 g, 74%) was prepared from 3-(methylsulfonyl)-5-(4-fluorophenyl)-1,2,4-triazine (5.00 g, 19.7 mmol) and 0.5 M ammonia in THF (100 mL, 50.0 mmol) according to the general procedure of Preparation 2.

Workup

  1. customaccording to the general procedure of Preparation 2

Sources & evidence

ORD record
ord-524d3b730c694b7d8138418910b95ba3
Source dataset
uspto-grants-2016_02
Patent number
US09249130B2

Reaction notes

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