Trifluoroacetic acid → HCID 53354109, compound

HRID 1771379Notes

Reaction equation

HRID 1771379 reaction equation
[NH2:1][C:2]1[N:3]=[N:4][C:5]([C:14]2[CH:15]=[CH:16][C:17]([N:20](C)[C:21](=O)[O-])=[N:18][CH:19]=2)=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:7]=1.FC(F)(F)C(O)=O>ClCCl>[CH3:21][NH:20][C:17]1[N:18]=[CH:19][C:14]([C:5]2[N:4]=[N:3][C:2]([NH2:1])=[N:7][C:6]=2[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86676122HCID 86676122, compound

Product 1

HCID 53354109HCID 53354109, compoundYield 71.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

6-(6-(Methylamino)pyridin-3-yl)-5-phenyl-1,2,4-triazin-3-amine (49.5 mg, 0.177 mmol, 71.4%) was prepared from 5-(3-amino-5-phenyl-1,2,4-triazin-6-yl)pyridin-2-yl(methyl)carbamate (vide supra), by BOC deprotection with trifluoroacetic acid (0.4 mL) in dichloromethane (1.6 mL) for 1 hour at room temperature.

Sources & evidence

ORD record
ord-a540679e163240c7840088eaeea78564
Source dataset
uspto-grants-2016_02
Patent number
US09249130B2

Reaction notes

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