Potassium Carbonate → HCID 118235991, compound

HRID 1771388Notes

Reaction equation

HRID 1771388 reaction equation
[NH2:1][C:2]1[N:6]([C:7]2[CH:8]=[CH:9][C:10]([OH:13])=[N:11][CH:12]=2)[N:5]=[C:4]([C:14]([CH3:17])([CH3:16])[CH3:15])[CH:3]=1.Cl.Cl[CH2:20][CH2:21][N:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1.C([O-])([O-])=O.[K+].[K+]>CC#N>[NH2:1][C:2]1[N:6]([C:7]2[CH:8]=[CH:9][C:10](=[O:13])[N:11]([CH2:20][CH2:21][N:22]3[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)[CH:12]=2)[N:5]=[C:4]([C:14]([CH3:17])([CH3:16])[CH3:15])[CH:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 77210Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1)HCID 178441178HCID 178441178, compound

Product 1

HCID 118235991HCID 118235991, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 5-(5-amino-3-(tert-butyl)-1H-pyrazol-1-yl)pyridin-2-ol (Abraham, S. et al., WO 2009/117080, 24 Sep. 2009) (4.04 g, 17.4 mmol) in MeCN (50 mL) was added 4-(2-chloroethyl)morpholine hydrochloride (3.88 g, 20.9 mmol) and K2CO3 (5.29 g, 38.3 mmol)

Sources & evidence

ORD record
ord-599946fc7b21479b82c772ee9e619c25
Source dataset
uspto-grants-2016_02
Patent number
US09249125B2

Reaction notes

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