Acetamide → HCID 71765898, compound

HRID 1771424Notes

Reaction equation

HRID 1771424 reaction equation
[NH:1]1[CH2:5][CH2:4][N:3]=[C:2]1[CH:6]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:16]#[N:17])[C:10]=2[CH2:9][CH2:8][O:7]1.C(N)(=[O:20])C.C1COCC1>Cl[Zn]Cl.O>[NH:3]1[CH2:4][CH2:5][N:1]=[C:2]1[CH:6]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:16]([NH2:17])=[O:20])[C:10]=2[CH2:9][CH2:8][O:7]1

Participants

6

Reactant 3

HCID 178AcetamideHCID 8028TetrahydrofuranHCID 71766907HCID 71766907, compound

Product 1

HCID 71765898HCID 71765898, compound

Reagents, catalysts & solvents 2

HCID 57277646-85-7CatalystHCID 962WaterSolvent

Procedure

The mixture of 1-(4,5-dihydro-1H-imidazol-2-yl)isochroman-5-carbonitrile (example 5, 75 mg), acetamide (39 mg), zink chloride (45 mg), THF (0.5 ml) and water (0.5 ml) was heated in a microwave reactor for 50 seconds at 320 W. The title compound was purified by applying method A. (Yield 15 mg).

Workup

  1. temperaturewas heated in a microwave reactor for 50 seconds at 320 W
  2. customThe title compound was purified

Sources & evidence

ORD record
ord-6038a7abf8234ff4bbe99a25a0c0e96e
Source dataset
uspto-grants-2016_02
Patent number
US09249127B2

Reaction notes

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