Hydrogen Bromide → HCID 71767645, compound

HRID 1771435Notes

Reaction equation

HRID 1771435 reaction equation
C[O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][O:9][CH:10]2[C:13]2[NH:14][CH2:15][CH2:16][N:17]=2)=[C:5]([CH3:18])[CH:4]=1.[BrH:19]>>[BrH:19].[NH:17]1[CH2:16][CH2:15][N:14]=[C:13]1[CH:10]1[C:11]2[C:6](=[C:5]([CH3:18])[CH:4]=[C:3]([OH:2])[CH:12]=2)[CH2:7][CH2:8][O:9]1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 71767501HCID 71767501, compound

Product 1

HCID 71767645HCID 71767645, compound

Procedure

2-(7-Methoxy-5-methylisochroman-1-yl)-4,5-dihydro-1H-imidazole (example 61, 100 mg) was dissolved in hydrobromic acid (1.5 mL, 47 w-% in water) and mixture was heated to reflux. After 5.5 hours mixture was cooled down to room temperature. Solvents were evaporated and the evaporation residue was triturated with ethanol to afford the title compound. (Yield 27 mg).

Workup

  1. temperaturemixture was heated to reflux
  2. customSolvents were evaporated
  3. customthe evaporation residue was triturated with ethanol

Sources & evidence

ORD record
ord-0265cf1f738140aa83c2d17745cc1d5e
Source dataset
uspto-grants-2016_02
Patent number
US09249127B2

Reaction notes

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