反应详情

To a stirred solution of 4-amino-2-fluorophenyl boronic acid pinacol ester (3.0 g, 12.7 mmol) in THF (10 ml) was added sodium hydrogen carbonate (1.6 g, 19.0 mmol) followed by phenyl chloroformate (1.9 ml, 15.2 mmol) and stirred overnight at room temperature. The reaction mixture was partitioned between DCM and water, the organic phase recovered, dried over Mg2SO4 and filtered before being concentrated in-vacuo to afford a white solid (4.95 g, quantitative).

1. customThe reaction mixture was partitioned between DCM and water
2. customthe organic phase recovered
3. dry with materialdried over Mg2SO4
4. filtrationfiltered
5. concentrationbefore being concentrated in-vacuo
6. customto afford a white solid (4.95 g, quantitative)