反应详情

温度

60 °C

To a solution of ethyl 2-[2,4-dichloro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetate (130 mg, 0.28 mmol, 1.0 eq) in THF (20 mL), LiOH.H2O (50 mg, 1.1 mmol, 4.0 eq) was added. After the addition of water (10 mL), the mixture was heated to 60° C. overnight. The THF was then removed in vacuo and the water phase was adjusted to pH 6 by addition of 1M HCl. The precipitate was collected by filtration, washed with water and dried in vacuo to give the title compound as a solid (80 mg, 65%).

1. customThe THF was then removed in vacuo
2. additionthe water phase was adjusted to pH 6 by addition of 1M HCl
3. filtrationThe precipitate was collected by filtration
4. washwashed with water
5. customdried in vacuo