反应详情

To a solution of isopropyl 2-[3-[[3-(3-fluorophenyl)-5-methyl-phenyl]methylamino]-2,4-dimethyl-phenoxy]acetate (114 mg, 0.26 mmol, 1.0 eq) in THF (10 mL) at 0° C. was added LiOH (2M aqueous solution, 4 mL, 8 mmol). The reaction mixture was allowed to warm to room temperature and stirred overnight. The THF was removed under reduced pressure and the aqueous solution that remained was diluted with water and adjusted to pH 4-6 by the addition of dilute HCl. The solid precipitate that formed was collected by filtration, washed with water and dried in vacuo to give title compound as a yellow solid (70 mg, 68%).

1. customThe THF was removed under reduced pressure
2. additionthe aqueous solution that remained was diluted with water
3. additionadjusted to pH 4-6 by the addition of dilute HCl
4. customThe solid precipitate that formed
5. filtrationwas collected by filtration
6. washwashed with water
7. customdried in vacuo