反应详情

To a solution of isopropyl 2-[3-[[5-(3-fluorophenyl)-2-methoxy-3-methyl-phenyl]methylamino]-2,4-dimethyl-phenoxy]acetate (155 mg, 0.33 mmol, 1.0 eq) in THF (4 mL) was added LiOH (2M aqueous solution, 4 mL, 8 mmol). The reaction mixture was stirred at room temperature for 2 h then the THF was removed under reduced pressure. The aqueous solution that remained was diluted with water and the pH adjusted to 4-6 with diluted HCl. The solid precipitate that formed was collected by filtration, washed with water and dried in vacuo to give a partially purified product. This material was further purified by preparative HPLC to give the title compound as a yellow solid (30 mg, 21%).

1. customthe THF was removed under reduced pressure
2. additionThe aqueous solution that remained was diluted with water
3. customThe solid precipitate that formed
4. filtrationwas collected by filtration
5. washwashed with water
6. customdried in vacuo
7. customto give a partially purified product
8. customThis material was further purified by preparative HPLC