反应详情

To a solution of isopropyl 2-[3-[[2-fluoro-3-(3-fluorophenyl)-5-methyl-phenyl]methylamino]-2,4-dimethyl-phenoxy]acetate (80 mg, 0.18 mmol, 1.0 eq) in THF (8 mL) at 0° C. was added LiOH (2M aqueous solution, 4 mL, 8.0 mmol). The reaction mixture was allowed to warm to room temperature and stirred overnight. The THF was removed and the remaining aqueous solution was diluted with water. The pH was adjusted to pH 4-6 by addition of diluted HCl. The solid precipitate that formed was collected by filtration, washed with water and dried in vacuo to give target compound as a yellow solid (30 mg, 41%).

1. customThe THF was removed
2. additionthe remaining aqueous solution was diluted with water
3. additionThe pH was adjusted to pH 4-6 by addition of diluted HCl
4. customThe solid precipitate that formed
5. filtrationwas collected by filtration
6. washwashed with water
7. customdried in vacuo