Hydrochloric Acid → HCID 22103383, compound

HRID 1772730Notes

Reaction equation

HRID 1772730 reaction equation
Cl.[Br:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][NH2:10])=[CH:5][CH:4]=1.Cl.O.[C:13]([OH:17])(=[O:16])[CH:14]=O>O>[Br:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9]/[N:10]=[CH:14]/[C:13]([OH:17])=[O:16])=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 121574-Bromophenylhydrazine hydrochlorideHCID 15620607Glyoxylic acid, monohydrate

Product 1

HCID 22103383HCID 22103383, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a stirred suspension of (4-bromophenyl)hydrazine HCl (2.01 g, 8.81 mmol) in water (20 mL) was added conc. HCl (1 mL) followed by glyoxylic acid monohydrate (811 mg, 8.81 mmol). The mixture was stirred vigorously at rt for 30 min and the light yellow suspension was filtered, washed with water (3×15 mL), and dried under suction followed by high vacuum to afford compound 84a as a light yellow solid, used without further purification in the following step. Mass spectrum (LCMS, ESI pos.): Calcd. for C8H7BrN2O2, 243.0/245.0 (M+H). found 243.2/245.1.

Workup

  1. filtrationthe light yellow suspension was filtered
  2. washwashed with water (3×15 mL)
  3. customdried under suction

Sources & evidence

ORD record
ord-f6b95b991eed4fccaa30072f7e93d8fd
Source dataset
uspto-grants-2016_02
Patent number
US09249163B2

Reaction notes

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