Toluene → 67191-92-8

HRID 1772805Notes

Reaction equation

HRID 1772805 reaction equation
[C:1](Cl)(Cl)=[O:2].C1(C)C=CC=CC=1.C(N(CC)CC)C.[F:19][C:20]1[CH:25]=[CH:24][C:23]([NH2:26])=[C:22]([CH3:27])[CH:21]=1>C1COCC1.C(Cl)Cl>[F:19][C:20]1[CH:25]=[CH:24][C:23]([N:26]=[C:1]=[O:2])=[C:22]([CH3:27])[CH:21]=1

Participants

7

Reactant 4

HCID 1140TolueneHCID 6371PhosgeneHCID 8471TriethylamineHCID 679824-Fluoro-2-methylaniline

Product 1

HCID 1241417167191-92-8

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8028TetrahydrofuranSolvent

Procedure

20% Phosgene in toluene (0.25 mL, 0.48 mmol) and triethylamine (0.11 mL, 0.76 mmol) were added to a solution of 4-fluoro-2-methyl-benzenamine (12 mg, 0.095 mmol) in a mixture of THF (0.30 mL) and DCM (0.10 mL). The reaction was stirred for two hours, then solvents were removed in vacuo and the product used without further purification in the next step.

Workup

  1. customsolvents were removed in vacuo
  2. customthe product used without further purification in the next step

Sources & evidence

ORD record
ord-706711a4d6e945d7b253909f3ce04889
Source dataset
uspto-grants-2016_02
Patent number
US09249145B2

Reaction notes

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