Triphosgene → HCID 90055161, compound

HRID 1772861Notes

Reaction equation

HRID 1772861 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([N:18]([CH3:20])[CH3:19])[N:13]=1)(=[O:10])=[O:9].Cl[C:22](Cl)([O:24]C(=O)OC(Cl)(Cl)Cl)Cl>O1CCOCC1>[CH3:19][N:18]([CH3:20])[C:14]1[N:13]=[C:12]([N:11]2[C:22](=[O:24])[NH:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=3[S:8]2(=[O:9])=[O:10])[CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 94429TriphosgeneHCID 90030819HCID 90030819, compound

Product 1

HCID 90055161HCID 90055161, compoundYield 26.4%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The title compound (0.20 g, 0.63 mmol) was prepared from 2-amino-N-[6-(dimethylamino)pyridin-2-yl]benzenesulfonamide (0.7 g, 2.39 mmol) and triphosgene (2.5 g, 8.3 mmol) in 1,4-dioxane (25 mL) using the methods of (IntA1).

Sources & evidence

ORD record
ord-58ac883ab4e84a2f8e08a8ec862cef32
Source dataset
uspto-grants-2016_02
Patent number
US09249160B2

Reaction notes

Loading…