Potassium Carbonate → 2-(3,4-Dimethoxyphenyl)-4-(2-fluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

HRID 1772940Notes

Reaction equation

HRID 1772940 reaction equation
[C:1]([O-])([O-])=[O:2].[K+].[K+].FC1C=CC=CC=1CBr.[CH3:16][O:17][C:18]1[C:23](C)=[CH:22][C:21]([N:25]2[C:30](=[O:31])[N:29]([CH2:32][C:33]3[C:38]([F:39])=[CH:37][C:36](F)=[CH:35][C:34]=3F)[C:28]3[CH:42]=[CH:43][CH:44]=[CH:45][C:27]=3[S:26]2(=[O:47])=[O:46])=[CH:20][C:19]=1C>CN(C=O)C>[CH3:1][O:2][C:19]1[CH:20]=[C:21]([N:25]2[C:30](=[O:31])[N:29]([CH2:32][C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][C:38]=3[F:39])[C:28]3[CH:42]=[CH:43][CH:44]=[CH:45][C:27]=3[S:26]2(=[O:46])=[O:47])[CH:22]=[CH:23][C:18]=1[O:17][CH3:16]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 67968alpha-Bromo-o-fluorotolueneHCID 727220852-(4-methoxy-3,5-dimethylphenyl)-4-(2,4,6-trifluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

Product 1

HCID 727211782-(3,4-Dimethoxyphenyl)-4-(2-fluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound (64 mg, 0.14 mmol) was prepared from (IntA1) (67 mg, 0.20 mmol), K2CO3 (83 mg, 0.60 mmol) and 2-fluorobenzyl bromide (45 mg, 0.24 mmol) in DMF (2 mL) using the methods of (115).

Sources & evidence

ORD record
ord-8775e808a9564ef3a8558b43f79a0943
Source dataset
uspto-grants-2016_02
Patent number
US09249160B2

Reaction notes

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