Dimethylformamide → HCID 72721796, compound

HRID 1772950Notes

Reaction equation

HRID 1772950 reaction equation
C([O-])([O-])=O.[K+].[K+].[Cl:7][C:8]1[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[C:9]=1[CH2:10]Br.[CH3:17][O:18][C:19]1C(C)=[CH:23][C:22]([N:26]2[C:31](=[O:32])[N:30](CC3C(F)=CC(F)=CC=3F)[C:29]3[CH:43]=[CH:44][CH:45]=[CH:46][C:28]=3[S:27]2(=[O:48])=[O:47])=[CH:21][C:20]=1C.C[N:51](C=O)C>>[Cl:7][C:8]1[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[C:9]=1[CH2:10][N:30]1[C:29]2[CH:43]=[CH:44][CH:45]=[CH:46][C:28]=2[S:27](=[O:48])(=[O:47])[N:26]([C:22]2[CH:23]=[N:51][C:19]([O:18][CH3:17])=[CH:20][CH:21]=2)[C:31]1=[O:32]

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 27736252-Chloro-6-fluorobenzyl bromideHCID 727220852-(4-methoxy-3,5-dimethylphenyl)-4-(2,4,6-trifluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

Product 1

HCID 72721796HCID 72721796, compound

Procedure

The title compound (79 mg, 0.18 mmol) was prepared from (IntA15) (75 mg, 0.25 mmol), K2CO3 (104 mg, 0.75 mmol) and 2-chloro-6-fluorobenzyl bromide (67 mg, 0.30 mmol) in DMF (2 mL) using the methods of (115).

Sources & evidence

ORD record
ord-b848eeba5df240a9802f49a8de6eb70a
Source dataset
uspto-grants-2016_02
Patent number
US09249160B2

Reaction notes

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