Potassium Carbonate → HCID 72721794, compound

HRID 1772951Notes

Reaction equation

HRID 1772951 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[S:10](=[O:12])(=[O:11])[N:9]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([S:19][CH3:20])[CH:14]=3)[C:8](=[O:21])[NH:7][C:6]=2[CH:22]=1.C([O-])([O-])=O.[K+].[K+].[Cl:29][C:30]1[CH:37]=[CH:36][CH:35]=[C:34]([F:38])[C:31]=1[CH2:32]Br>CN(C=O)C>[Cl:29][C:30]1[CH:37]=[CH:36][CH:35]=[C:34]([F:38])[C:31]=1[CH2:32][N:7]1[C:6]2[CH:22]=[C:2]([F:1])[CH:3]=[CH:4][C:5]=2[S:10](=[O:12])(=[O:11])[N:9]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([S:19][CH3:20])[CH:14]=2)[C:8]1=[O:21]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 27736252-Chloro-6-fluorobenzyl bromideHCID 118046033HCID 118046033, compound

Product 1

HCID 72721794HCID 72721794, compoundYield 46.1%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound (74 mg, 0.15 mmol) was subsequently prepared from 6-fluoro-2-[3-(methylsulfanyl)phenyl]-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide (110 mg), K2CO3 (180 mg, 1.30 mmol) and 2-chloro-6-fluorobenzyl bromide (89 uL, 0.65 mmol) in DMF (5 mL) using the methods of (115).

Sources & evidence

ORD record
ord-9312d985732f4407ac15310f2c9b73df
Source dataset
uspto-grants-2016_02
Patent number
US09249160B2

Reaction notes

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