HRID1772957

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID3354272

2,6-Difluoro-4-methoxybenzyl bromide

C8H7BrF2O

结构：COc1c(C)cc(N2C(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc3S2(=O)=O)cc1C

HCID72722085

未命名化合物

结构：COc1ncc(N2C(=O)Nc3ccccc3S2(=O)=O)cc1C

HCID90055107

未命名化合物

PRODUCTS

生成物

结构：COc1cc(F)c(CN2C(=O)N(c3cnc(OC)c(C)c3)S(=O)(=O)c3ccccc32)c(F)c1

HCID72720777

未命名化合物

收率 26%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

The title compound (60 mg, 0.13 mmol) was prepared from 2-(6-methoxy-5-methylpyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide (IntA28) (161 mg, 0.50 mmol), 2,6-difluoro-4-methoxybenzyl bromide (179 mg, 0.76 mmol) and K2CO3 (104 mg, 0.75 mmol) in DMF (3 mL) using the methods of (115).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ba0affdc10214aefa12539c7dcf4eb71
来源数据集: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09249160B2
来源说明: uspto-grants-2016_02

反应 SMILES

[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([N:9]2[C:14](=[O:15])[NH:13][C:12]3[CH:16]=[CH:17][CH:18]=[CH:19][C:11]=3[S:10]2(=[O:21])=[O:20])=[CH:5][C:4]=1[CH3:22].[F:23][C:24]1[CH:31]=[C:30]([O:32][CH3:33])[CH:29]=[C:28]([F:34])[C:25]=1[CH2:26]Br.C([O-])([O-])=O.[K+].[K+].COC1C(C)=CC(N2C(=O)N(CC3C(F)=CC(F)=CC=3F)C3C=CC=CC=3S2(=O)=O)=CC=1C>CN(C=O)C>[F:23][C:24]1[CH:31]=[C:30]([O:32][CH3:33])[CH:29]=[C:28]([F:34])[C:25]=1[CH2:26][N:13]1[C:12]2[CH:16]=[CH:17][CH:18]=[CH:19][C:11]=2[S:10](=[O:21])(=[O:20])[N:9]([C:6]2[CH:7]=[N:8][C:3]([O:2][CH3:1])=[C:4]([CH3:22])[CH:5]=2)[C:14]1=[O:15]