Triethylamine → HCID 68586360, compound

HRID 1773005Notes

Reaction equation

HRID 1773005 reaction equation
[C:1]1([O:11][CH2:12][CH:13]2[CH2:15][O:14]2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[Br-:16].[NH3+:17][CH2:18][CH2:19][CH2:20][N+:21]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[C:24]([CH3:31])=[CH:23][CH:22]=1.[Br-].C(N(CC)CC)C>O>[Br-:16].[OH:14][CH:13]([CH2:12][O:11][C:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1)[CH2:15][NH:17][CH2:18][CH2:19][CH2:20][N+:21]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[C:24]([CH3:31])=[CH:23][CH:22]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 915212-((1-Naphthalenyloxy)methyl)oxiraneHCID 68587788HCID 68587788, compound

Product 1

HCID 68586360HCID 68586360, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a suspension of Compound 1 (0.17 g, 0.83 mmol) and Compound 2 (0.30 g, 0.83 mmol) in water (1 mL), triethylamine (0.10 g, 0.99 mmol) was added. The combined mixture was stirred at room temperature for 24 hours and then evaporated in the rotary evaporator to provide Compound 3 as a solid. This product was used without any workup and further purification. The structure of Compound 3 is given below:

Workup

  1. additionwas added
  2. customevaporated in the rotary evaporator

Sources & evidence

ORD record
ord-f07f85d1785a4a11ba6d741fdea4311c
Source dataset
uspto-grants-2016_02
Patent number
US09250249B2

Reaction notes

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