Succinic anhydride → HCID 43529230, compound

HRID 1773064Notes

Reaction equation

HRID 1773064 reaction equation
[C:1]1(=[O:7])[O:6][C:4](=[O:5])[CH2:3][CH2:2]1.[CH2:8]([NH2:11])[C:9]#[CH:10]>O1CCCC1>[O:7]=[C:1]([NH:11][CH2:8][C:9]#[CH:10])[CH2:2][CH2:3][C:4]([OH:6])=[O:5]

Participants

4

Reactant 2

HCID 7922Succinic anhydrideHCID 239041Propargylamine

Product 1

HCID 43529230HCID 43529230, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1.6 g (16 mmol) Succinic anhydride and 1.06 g (19.2 mmol) propargylamine in 10 ml tetrahydrofuran were stirred over night at room temperature whereat a solid precipitated. The reaction mixture was taken up with methyl-t-butyl ether (MTBE) and the insoluble crystals were filtered off and dried in a stream of nitrogen. 2 g (80% of theory) of the title compound were obtained which were used in the next reaction without further purification.

Workup

  1. customprecipitated
  2. filtrationthe insoluble crystals were filtered off
  3. customdried in a stream of nitrogen

Sources & evidence

ORD record
ord-fc402cfb25d841cebdf471d014417eec
Source dataset
uspto-grants-2016_02
Patent number
US09253980B2

Reaction notes

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