反应详情

A flask was charged with sodium hydride 60% (0.803 mg, 20.12 mmol) in DMF and stirred at RT for 10 min. 2,8-Dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (1.28 g, 6.4 mmol) was added and the mixture stirred at RT for 1 h. 2-(4-Methoxyphenyl)-2-methyloxirane (1.5 g, 9.14 mmol) was added and the mixture stirred at RT overnight. Ice water was added and the mixture extracted with ethyl acetate (3×). The combined organic layers were washed with water (4×) and concentrated, followed by purification of the product on silica gel (#100-200 mesh) using 0-5% MeOH:DCM as eluent.

1. stirringthe mixture stirred at RT for 1 h
2. stirringthe mixture stirred at RT overnight
3. extractionthe mixture extracted with ethyl acetate (3×)
4. washThe combined organic layers were washed with water (4×)
5. concentrationconcentrated
6. customfollowed by purification of the product on silica gel (#100-200 mesh)