Hydrochloric Acid → HCID 118412452, compound

HRID 1773479Notes

Reaction equation

HRID 1773479 reaction equation
[NH:1]1[CH2:6][CH:5]=[N:4][C:3]2[N:7]([C:10]#[C:11][C:12]3[CH:13]=[C:14]([CH:36]=[CH:37][C:38]=3[CH3:39])[C:15]([NH:17][C:18]3[CH:23]=[CH:22][C:21]([CH2:24][N:25]4[CH2:30][CH2:29][N:28]([CH3:31])[CH2:27][CH2:26]4)=[C:20]([C:32]([F:35])([F:34])[F:33])[CH:19]=3)=[O:16])[CH:8]=[CH:9][C:2]1=2.[ClH:40]>CO.C(OCC)(=O)C>[ClH:40].[NH:1]1[CH2:6][CH:5]=[N:4][C:3]2[N:7]([C:10]#[C:11][C:12]3[CH:13]=[C:14]([CH:36]=[CH:37][C:38]=3[CH3:39])[C:15]([NH:17][C:18]3[CH:23]=[CH:22][C:21]([CH2:24][N:25]4[CH2:26][CH2:27][N:28]([CH3:31])[CH2:29][CH2:30]4)=[C:20]([C:32]([F:35])([F:34])[F:33])[CH:19]=3)=[O:16])[CH:8]=[CH:9][C:2]1=2

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 118412453HCID 118412453, compound

Product 1

HCID 118412452HCID 118412452, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

The compound (3-((1H-pyrrolo[2,3-b]pyrazin-5-yl)ethynyl)-4-methyl-N-[4-((4-methylpiperazin-1-yl)methyl)-3-trifluoromethylphenyl]benzamide) (30 mg) prepared in Example 3 was weighed, dissolved in 5 ml methanol, and a solution of hydrogen chloride in ethyl acetate was added dropwise to a pH of about 3. The mixture was stirred at room temperature for 3 hours. The volatiles were evaporated under reduced pressure, and the residue was dried under vacuum at 50° C. for 5 hours, to give the title compound.

Workup

  1. customThe volatiles were evaporated under reduced pressure
  2. customthe residue was dried under vacuum at 50° C. for 5 hours

Sources & evidence

ORD record
ord-0e91a33f6f0a4b5490c39eb54826cc42
Source dataset
uspto-grants-2016_02
Patent number
US09255107B2

Reaction notes

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