Hydrochloric Acid → HCID 58056251, compound

HRID 1773568Notes

Reaction equation

HRID 1773568 reaction equation
C([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[CH:14]=[C:13]([CH2:15][CH2:16][CH2:17][OH:18])[CH:12]=[N:11][C:10]=12)=[O:5])C.Cl>[OH-].[Na+]>[OH:18][CH2:17][CH2:16][CH2:15][C:13]1[CH:12]=[N:11][C:10]2[N:9]([N:8]=[CH:7][C:6]=2[C:4]([OH:5])=[O:3])[CH:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 580563146-(3-Hydroxy-propyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester

Product 1

HCID 58056251HCID 58056251, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideCatalyst

Procedure

A mixture of 6-(3-hydroxy-propyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester (5 mg) and an aqueous solution of sodium hydroxide (5 drops) was stirred at room temperature for 16 hours. The reaction mixture was then acidified by addition of an aqueous solution of hydrochloric acid (3 M). The precipitate was collected by filtration to give 6-(3-hydroxy-propyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid. MS=222 [M+H]+.

Workup

  1. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-6eecbdc672d54e9b9500e6939deb5dc7
Source dataset
uspto-grants-2016_02
Patent number
US09255110B2

Reaction notes

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