Hydrochloric Acid → 3-Bromo-4-(trifluoromethoxy)benzoic acid
Reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][C:11]([F:14])([F:13])[F:12])[CH:5]=[O:6].[OH:15]O.Cl>CO.[OH-].[Na+]>[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][C:11]([F:12])([F:13])[F:14])[C:5]([OH:15])=[O:6]Participants
6
Conditions
- Temperature
- 0 °C
Procedure
To an ice-cooled solution of 3-bromo-4-(trifluoromethoxy)benzaldehyde (3.00 g, 11.2 mmol, 1 eq.) in MeOH (14 mL), a solution of hydrogen peroxide (30% wt solution in water, 14 mL, 11.2 mmol, 1 eq.) in 15% aq. NaOH soln. (14 mL) was added dropwise. The reaction mixture was stirred at 0° C. for 1 hour and further at r.t. for 18 hours. The reaction mixture was acidified by addition of conc. HCl. The suspension was filtered off and the filter cake was rinsed with H2O. The resulting white solid was dried under h.v. to give the title compound. The product was used without further purification.
Workup
- addition(14 mL) was added dropwise
- filtrationThe suspension was filtered off
- washthe filter cake was rinsed with H2O
- customThe resulting white solid was dried under h.v
Sources & evidence
- ORD record
- ord-2f3609b69d7549179c6830933b59da0a
- Source dataset
- uspto-grants-2016_02
- Patent number
- US09255090B2
Reaction notes
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