反应详情

To a solution of ethyl 4-aminophenylacetate (1.79 g, 10 mmol, 1 eq.) in MeCN (50 mL), N-bromsuccinimide (1.78 g, 10 mmol, 1 eq.) was added slowly. The mixture was stirred at r.t. for 72 hours. The reaction mixture was concentrated in vacuo. The residue was partitioned between water (50 mL) and Et2O (50 mL). The org. phase was washed with sat. aq. NaCl soln. (1×50 mL), dried over MgSO4, and concentrated in vacuo to give (4-amino-3-bromo-phenyl)-acetic acid ethyl ester as an orange oil. The product was used without further purification.

1. concentrationThe reaction mixture was concentrated in vacuo
2. customThe residue was partitioned between water (50 mL) and Et2O (50 mL)
3. washphase was washed with sat. aq. NaCl soln
4. dry with material(1×50 mL), dried over MgSO4
5. concentrationconcentrated in vacuo