Sodium Bicarbonate → HCID 86696680, compound

HRID 1774183Notes

Reaction equation

HRID 1774183 reaction equation
F[C:2]1[CH:7]=[C:6]([C:8]2[C:13]([CH3:14])=[CH:12][N:11]=[C:10]([NH:15][CH:16]3[CH2:21][CH2:20][O:19][CH2:18][CH2:17]3)[N:9]=2)[CH:5]=[CH:4][N:3]=1.C([O-])(O)=[O:23].[Na+]>Cl>[CH3:14][C:13]1[C:8]([C:6]2[CH:5]=[CH:4][NH:3][C:2](=[O:23])[CH:7]=2)=[N:9][C:10]([NH:15][CH:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)=[N:11][CH:12]=1

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 86696681HCID 86696681, compound

Product 1

HCID 86696680HCID 86696680, compoundYield 80.3%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

1M HCl (10 mL) was added to 4-(2-fluoropyridin-4-yl)-5-methyl-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-2-amine (0.158 g, 0.548 mmol). The mixture was heated at reflux. After 2 hours, the cooled reaction mixture was neutralized with solid NaHCO3. The resulting solid was collected by vacuum filtration and dried to afford 4-(5-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-4-yl)pyridin-2(1H)-one (0.126 g, 0.440 mmol, 80.3% yield) as a solid.

Workup

  1. temperatureThe mixture was heated
  2. temperatureat reflux
  3. customthe cooled reaction mixture
  4. filtrationThe resulting solid was collected by vacuum filtration
  5. customdried

Sources & evidence

ORD record
ord-750d4da9aa5c4d5281ed592f2a6d3fac
Source dataset
uspto-grants-2016_02
Patent number
US09259470B2

Reaction notes

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